The pathogenesis of hyperuricemia and gout in sickle cell anemia
Open Access
- 1 November 1970
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 13 (6) , 846-848
- https://doi.org/10.1002/art.1780130614
Abstract
A patient with sickle cell disease complicated by gouty arthritis is reported. Studies with 14C labeled uric acid and glycine, and discrete renal function tests indicate that both overproduction of uric acid and diminished excretion of urate due to decreased nephron mass contributed to hyperuricemia.Keywords
This publication has 10 references indexed in Scilit:
- Sickle cell anemia and hyperuricemiaPublished by American Medical Association (AMA) ,1968
- The renal mechanism for urate homeostasis in normal manThe American Journal of Medicine, 1967
- Suppression of the shunt pathway in primary gout by azathioprine.Proceedings of the National Academy of Sciences, 1966
- The Pathogenesis of GoutArchives of internal medicine (1960), 1962
- IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUIDAnnals of Internal Medicine, 1961
- A simultaneous study of glycine-N15 incorporation into uric acid and heme, and of Fe59 utilization, in a case of gout associated with polycythemia secondary to congenital heart diseaseThe American Journal of Medicine, 1953
- Determination of Inulin by Means of ResorcinolExperimental Biology and Medicine, 1950
- An Enzymatic Method for the Determination of Uric Acid by Ultraviolet SpectrofhotometryScandinavian Journal of Clinical and Laboratory Investigation, 1949