Wound Healing: Investigation of Proteins, Glycoproteins, and Lipids of Experimental Wound Fluid in the Dog

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Abstract
Surgical implants of stainless steel mesh cylinders were made into subcutaneous tissue of dog's back. These were removed at intervals of 1 to 4 weeks. Wound fluid was aspirated from inside these cylinders encapsulated with fibrous tissue. When compared with animal's serum, this fluid was lower in protein, glycoprotein, and lipid; and these components decreased with time during post-wound period. As studied by paper electrophoresis, wound fluid had a higher per cent of albumin and lower alpha-2 and beta-1 globulin. An elevation of protein-bound hexose was found in beta and gamma globulin fractions at 3 to 4 weeks. Seromucoid was present at same level in wound fluid and serum. The lipid partition revealed especially low phosphatides but similar cholesterol:protein ratios. It appears that time-related changes occur in large molecular constituents of fluid found in wound area which may be significant in wound healing phenomenon.

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