Electrophoretic Examination of Cerebrospinal Fluid Proteins in Multiple Sclerosis and Other Neurological Diseases

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Abstract
Cerebrospinal fluid from 401 neurological patients was examined by means of cellulose acetate electrophoresis. Of these, 145 were also examined by agarose gel electrophoresis. Cellulose acetate electrophoresis revealed a pronounced relative increase of γ-globulins in subacute sclerosing panencephalitis and in multiple sclerosis, and a moderate increase in chronic inflammatory disorders of the central nervous system. An increase was also found in some cases of slowly progressive central nervous system diseases, such as slowly progressive encephalopathy or myelopathy. In cases with elevated γ-globulins, agarose gel electrophoresis revealed abnormal patterns with one or more (up to seven) homogenous γ-bands in 90% of the patients with multiple sclerosis, and in 37% with other neurological diseases. Compared with the distribution of serum γ-globulins, a definite cathodic shift of cerebrospinal fluid γ-zones was evident in multiple sclerosis and in subacute sclerosing panencephalitis.

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