Stability of Lidocaine in Aqueous Solution: Effect of Temperature, pH, Buffer, and Metal Ions on Amide Hydrolysis
- 1 January 1987
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 04 (1) , 42-45
- https://doi.org/10.1023/a:1016477810629
Abstract
The degradation of lidocaine in aqueous solution obeys the expression kobs = ( kH+[H +] + ko ) [H+]/([H + ] + Ka + k′o Ka([H + ] + Ka) where kH+ is the rate constant for hydronium ion catalysis, and kThis publication has 8 references indexed in Scilit:
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