Effect of a Single Dose of N-Diethylnitrosamine on the Rat Kidney
- 1 December 1972
- journal article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 49 (6) , 1729-1731
- https://doi.org/10.1093/jnci/49.6.1729
Abstract
A single intravenous injectionof 1.25-160 mg N-diethylnitrosamine (DEN)/kg body weight (geometric progression) was given to male and female Sprague-Dawley rats. A dose of 1.25 mg DEN/kg body weight induced a kidney adenoma in 1 female. The high doses of DEN increased the tumor incidence and the number of kidney carcinomas and decreased survival, especially in females. Epithelial tumors (tubulary adenomas and carcinomas) were mainly found; only 1 animal had a malignant mesenchymal neoplasm.Keywords
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