A method for the evaluation of some oral prolonged-release forms of dexamphetamine in man, using urinary excretion data
- 1 December 1966
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 18 (Supplement) , 72S-75S
- https://doi.org/10.1111/j.2042-7158.1966.tb07964.x
Abstract
ALTHOUGH urinary excretion studies (Campbell, Nelson & Chapman, 1959; Chapman, Shenoy & Campbell, 1959; Shenoy, Chapman & Campbell, 1959) have been used as a technique to evaluate prolonged-release dosage forms of amphetamine, the significance of the results is in doubt because of the use of non-specific assay methods and the failure to control urinary pH. The use of radioactive material has indicated the similarity between a dose of 5 mg amphetamine three times a day and a 15 mg prolonged release preparation (Rosen, Tannenbaum, Ellison, Free & Crosley, 1965).Keywords
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