Snail and Slug Play Distinct Roles during Breast Carcinoma Progression
Top Cited Papers
Open Access
- 15 September 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (18) , 5395-5402
- https://doi.org/10.1158/1078-0432.ccr-06-0478
Abstract
Purpose: Carcinoma progression is linked to a partially dedifferentiated epithelial cell phenotype. As previously suggested, this regulation could involve transcription factors, Snail and Slug, known to promote epithelial-mesenchymal transitions during development. Here, we investigate the role of Snail and Slug in human breast cancer progression.Keywords
All Related Versions
This publication has 29 references indexed in Scilit:
- The transcriptional repressor Snail promotes mammary tumor recurrenceCancer Cell, 2005
- SLUG in cancer developmentOncogene, 2005
- Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor MetastasisCell, 2004
- Snail blocks the cell cycle and confers resistance to cell deathGenes & Development, 2004
- A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 geneGenes, Chromosomes and Cancer, 2003
- Correlation of Snail expression with histological grade and lymph node status in breast carcinomasOncogene, 2002
- The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expressionNature Cell Biology, 2000
- The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cellsNature Cell Biology, 2000
- The slug gene is not essential for mesoderm or neural crest development in miceDevelopmental Biology, 1998
- Isolation and growth of human mammary epithelial cellsJournal of Tissue Culture Methods, 1985