Effect of Chronic Lead Intoxication on in vivo I131 Uptake By the Rat Thyroid.

Publisher Website
Google Scholar
Abstract
Male and female Sprague-Dawley rats were chronically intoxicated with lead acetate. After 8 to 14 mo. in vivo thyroid uptake of I131 was determined at 1, 2, 3, 6 and 24 hrs. The uptake was significantly decreased in the intoxicated female rats at all times. Intoxicated male rats had significantly decreased RAI uptake as a group at 2 and 3 hours compared to the control males. Conversion ratios were significantly decreased in both intoxicated groups of male and female rats compared to controls of the same sex and age. In vitro RAI [Radioactive iodide] uptakes were similar to the in vivo uptakes in all animals. Thiocyanate tests did not show evidence of a lesion in organification of I13l by the lead-intoxicated rat thyroid gland.