Experimental Removal of 144Ce, 241Am, 242Cm and 238Pu from the Rat Skeleton
- 1 November 1972
- journal article
- research article
- Published by Wolters Kluwer Health in Health Physics
- Vol. 23 (5) , 635-640
- https://doi.org/10.1097/00004032-197211000-00005
Abstract
The therapeutic effectiveness of DTPA on bone deposits of lanthanide or transuranic elements can be appreciable when the greater part of the activity is to be found in bone. This was obtained after 3 weeks time following the administration by inhalation of 144Ce and 241Am and by intramuscular injection of 242Cm and 238Pu DTPA therapy starting after this delay decreased bone burdens by a factor from 1/2 to 1/3 in 3 months. There probably exist two different compartments which would clear, under the influence of DTPA, with a half life of 2 months for the former and very slowly for the latter. The effectiveness of DTPA on the second compartment could not be estimated.Keywords
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