THERAPEUTIC USE OF GENTAMICIN IN HORSES - CONCENTRATIONS IN SERUM, URINE, AND SYNOVIAL-FLUID AND EVALUATION OF RENAL-FUNCTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (7) , 1085-1087
Abstract
Serum, synovial fluid and urine concentrations of gentamicin were measured in normal mature horses which were given a single dose of the drug. Mean peak serum concentration (16.8 .mu.g/ml) occurred in horses 30 min after they were given a single i.m. dose of 4.4 mg of gentamicin/kg of body weight. In horses given a smaller dose of gentamicin (1.7 mg/kg), mean peak serum concentrations of gentamicin (10.2 .mu.g/ml) appeared at 1 h. Synovial fluid concentration was maximum at 2 h for both doses; in horses given the larger dose, mean peak concentration was 6.4 .mu.g/ml, and in those given the smaller dose (1.7 mg/kg), 3.4 .mu.g/ml. Measurable concentrations of gentamicin in serum and synovial fluid persisted 8 h. During the 1st 8 hours, percentages of gentamicin excreted in the urine were between 3.9-32.8% of the larger dose and between 3.3-13.4% of the smaller dose. Serum creatinine concentrations were serially measured in 10 hospitalized horses i.m. given 1.7-4.4 mg of gentamicin/kg 4 times a day; significant increase in creatinine concentration was not found.

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