Ribonucleotide Reductase Targets for Chemotherapy; Mechanistic Aspects and Biologically Active Agents
- 1 May 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 14 (3) , 485-493
- https://doi.org/10.1080/15257779508012411
Abstract
Ribonucleotide reductases are essential for the de novo biosynthesis of the 2′-deoxynucleotide components of DNA. These enzymes have complex cofactors and execute novel chemistry involving C2′ via radical abstraction of H3′. Mechanistic aspects of these transformations and selected nucleotide analogues that cause mechanism-based inactivation of ribonucleotide reductases are discussed.Keywords
This publication has 0 references indexed in Scilit: