A new technique for drug susceptibility tests for Plasmodium falciparum by ethidium bromide fluoroassay
- 1 January 1986
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 80 (1) , 47-49
- https://doi.org/10.1016/0035-9203(86)90192-6
Abstract
When Plasmodium falciparum parasites were stained with the fluorescent dye ethidium bromide, the fluorescence intensity of the solubilized parasites was correlated with the amount of nucleic acid present. It was possible to monitor development of the parasites from ring form to schizont by the fluoroassay. The assay system was applied to in vitro drug susceptibility tests on malaria parasites.Keywords
This publication has 7 references indexed in Scilit:
- A fluorescent complex between ethidium bromide and nucleic acids: Physical—Chemical characterizationPublished by Elsevier ,2004
- Maintenance and propagation of human malaria parasites in culture using an ordinary CO2 incubatorTransactions of the Royal Society of Tropical Medicine and Hygiene, 1984
- Effects of qinghaosu and related compounds on incorporation of [G-3H]hypoxanthine by Plasmodium falciparum in vitroTransactions of the Royal Society of Tropical Medicine and Hygiene, 1983
- In vitro microtechnique for determining the drug susceptibility of cultured parasites of Plasmodium falciparumTransactions of the Royal Society of Tropical Medicine and Hygiene, 1980
- Chloroquine Resistance Produced in Vitro in an African Strain of Human MalariaScience, 1978
- DRUG SENSITIVITY OF PLASMODIUM FALCIPARUMThe Lancet, 1978
- Human Malaria Parasites in Continuous CultureScience, 1976