EFFECT OF LOW-LEVEL EXPOSURE TO OZONE ON ARTERIAL OXYGENATION IN HUMANS

Abstract
The effect on arterial blood oxygenation of exposure to 0.2 ppm of the air pollutant O3 in purified air for 2 h with intermittent light exercise and heat stress was investigated. Similar exposures to purified air alone provided control data. In 12 healthy volunteers, blood gases were measured before and during exposure via an indwelling brachial cannula. Six of these subjects and 6 other subjects underwent separate similar studies in which arterialized earlobe capillary blood was sampled. Arterial partial pressure of O2 [PO2] and alveolar-arterial PO2 differences varied significantly among different experimental conditions, but the variability was similar in the presence or absence of O3. Small significant variations in body temperature were observed; these did not appear sufficient to affect blood gas measurements substantially. No evidence for an adverse effect of the exposure to O2 on arterial oxygenation was found.

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