Role of Soy Diet and L‐Arginine in Cyclosporin‐A‐Induced Osteopenia in Rats

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Abstract
Our previous studies show that chronic administration of L‐arginine decreases cyclosporin‐A‐induced bone loss. The present study was designed to investigate whether a soy diet could prevent cyclosporin A‐induced osteopenia and eventually improve the protective effect of L‐arginine. Rats on soy diet were treated with cyclosporin‐A, L‐arginine, cyclosporin‐A+L‐arginine or saline. Control groups received a normal diet and the same pharmacological treatment. Our results show that a soy diet prevents osteopenia only in the spinal cord (+30%) and confirm the protective effect of L‐arginine in cyclosporin‐A‐induced osteopenia in whole body, pelvis and spine of rats on a normal diet (+31%, +55%, +55%, respectively). Moreover these data show that the osteoprotective effect of L‐arginine in the whole body, pelvis and spine improves in the case of soy diet (+60%, +72%, +89%, respectively). The results suggest that a soy diet exerts a positive effect in cyclosporin‐A‐induced osteopenia only in sites with high turn‐over and improves the osteoprotective effect of L‐arginine.

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