Pharmacodynamic Model Describing the Growth of a Mammary Carcinoma in the Mouse Under the Influence of Adriamycin Treatment

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Abstract
The chemotherapeutic effects of different doses of adriamycin in (C3H .times. 020)F1 mice bearing mammary carcinoma were investigated and a model of the growth of neoplastic cells under the influence of treatment is described. An estimate of cell kill and of the fraction of cells surviving after treatment is given by the efficacy constant K, which is a function of the dose level of the drug. The therapeutic value of each treatment is also related to the degree of toxicity which is expressed by the probability of death for each dose level.