Dibutyryl cyclic GMP, a competitive inhibitor of cholecystokinin/pancreozymin and related peptides in the gallbladder and ileum

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Abstract
Dibutyryl cyclic GMP (dbcGMP), a known selective inhibitor of the effects of cholecystokinin/pancreozymin (CCK/Pz) in the pancreas, shows a similar selective antagonism of the motor-stimulating actions of CCK/Pz in guinea pig gallbladder and ileum. The inhibition is reversible and competitive. Hence, dbcGMP could be used to identify physiological mechanisms which utilize CCK/Pz. Since dbcGMP abolished the peristaltic reflex it is suggested that CCK/Pz may be utilized as a transmitter in the nerve pathways of the reflex.

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