Collagen Polymorphism: Characterization of Molecules with the Chain Composition [α1(III)] 3 in Human Tissues
- 22 March 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4130) , 1200-1201
- https://doi.org/10.1126/science.183.4130.1200
Abstract
Collagen molecules with the chain composition [α1(III)] 3 , have been isolated from pepsin-solubilized collagen of dermis, aorta, and leiomyoma of the uterus by differential salt precipitation. On denaturation, approximately 90 percent of this collagen is recovered as a γ component (300,000 daltons). Reduction and alkylation of the high-molecular-weight component yields α1(III) chains (95,000 daltons). In addition to containing cysteine, α1(III) chains exhibit several other compositional differences when compared to α1(I), α1(II), or α2 chains from human tissues.Keywords
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