Liposome accumulation in ischaemic intestine following experimental mesenteric occlusion

Publisher Website
Google Scholar
Abstract
Whether liposomal accumulation is unique to ischemic myocardium or is a general feature of ischemia per se irrespective of anatomical site was studied. Partial intestinal ischemia was produced by ligation of selected primary laterals of the mesenteric artery in the rat. Both positively and negatively charged liposomes (multiply labeled with [99mTc]diethylenetriamine pentaacetic acid, [3H]methoxy-inulin and [4-14C]-cholesterol), administered 24 h following ligation, were accumulated in ischemic (necrotic) intestine.