INFLUENCE OF RESPIRATORY-ACIDOSIS AND ALKALOSIS ON VOLUME OF DISTRIBUTION OF THEOPHYLLINE IN DOGS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (3) , 643-646
Abstract
The volume of distribution of theophylline at normal pH, and following induction of respiratory acidosis and alkalosis, was studied in 4 dogs in a 3 way crossover design. Although serum half-lives of theophylline varied widely, and acidemia prolonged the time required for distribution equilibration, the volumes of distribution were almost identical for each of the 3 experimental conditions assuming 1 compartment pharmacokinetics apply.

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