Microbial Transformation of (−)‐Δ1‐3,4‐trans‐Tetrahydrocannabinol by Cunninghamella blakesleeana LENDER
- 14 July 1976
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 59 (5) , 1674-1684
- https://doi.org/10.1002/hlca.19760590528
Abstract
Incubation of (−)‐Δ1‐3, 4‐trans‐tetrahydrocannabinol (= Δ1‐THC; 3) with stationary cultures of Cunninghamella blakesleeana LENDER (Zygomycetales) (ATCC 8688a) yielded a number of metabolic conversion products. Isolation and structure elucidation of 6α‐hydroxy‐Δ1‐THC (4), the potential psychoactive 3″‐hydroxy‐Δ1‐THC (2) and 4″‐hydroxy‐Δ1‐THC (1), and the hitherto unknown metabolites 4″‐hydroxy‐6‐oxo‐Δ1‐THC (5), 4″, 6α‐dihydroxy‐Δ1‐THC (7) and 4″, 7‐dihydroxy‐Δ1‐THC (6) is described.This publication has 15 references indexed in Scilit:
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