Control of hepatic triacylglycerol synthesis. Diurnal variations in hepatic phosphatidate phosphohydrolase activity and in the concentrations of circulating insulin and corticosterone in rats

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Abstract
Male rats were kept for 14 days with alternating 12 h periods of light and darkness. The hepatic activity of soluble phosphatidate phosphohydrolase [EC 3.1.3.4] and the concentration of serum insulin were maximum at about 2 h after dark. The peak concentration of serum corticosterone occurred 2 h before the dark period. Corticosterone is evidently partly responsible for the increased phosphohydrolase activity and this enables the liver to increase its capacity to synthesize triacylglycerols during the period of maximum feeding.

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