Synthesis of tritium labelled diphenhydramine hydrochloride (benadryl )
- 5 July 1967
- journal article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 3 (3) , 245-250
- https://doi.org/10.1002/jlcr.2590030308
Abstract
The synthesis and characterization of tritium‐labelled diphenhydramine hydrochloride is described. An attempt to label diphenhydramine directly with tritium by an exchange reaction (CH3COOH, 10 c 3H2O, Pt) resulted in a mixture of tritiated benzophenone, benzhydrol, diphenhydramine, and other products. A mixture of tritiated benzophenone and benzhydrol was isolated, reduced to benzhydrol‐3H, and then condensed with dimethylaminoethanol to yield diphenhydramine‐3H with the label in the benzhydryl group.Keywords
This publication has 4 references indexed in Scilit:
- The labelling with tritium of 2‐(dimethylamino)ethanol and of some drugs containing the 2‐(dimethylamino)ethyl group as a structural partJournal of Labelled Compounds and Radiopharmaceuticals, 1966
- BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL)Published by Elsevier ,1949
- BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL)Published by Elsevier ,1949
- BIOCHEMICAL STUDIES ON DIPHENHYDRAMINE (BENADRYL)Published by Elsevier ,1949