Distribution and elimination of 14C-xylene in rat.

Publisher Website
Google Scholar
Abstract
Male rats were exposed to .apprx. 45 ppm 14C-xylene in inspired air for 1-8 h. The distribution and elimination of xylene and metabolites in different organs and tissues were studied. To get an idea of the ratio between unmetabolized and metabolized xylene in organs and tissues, a supplementary study was performed in which 5 male rats were exposed to .apprx. 250 ppm 14C-xylene. The concentration of xylene and metabolites in the s.c. fat, where the largest amounts were found, displayed a sharp rise during the first 4 h of exposure compared with the following 4 h. During exposure and decay phase the concentration of xylene and its metabolites in the cerebrum, cerebellum and muscles paralleled arterial blood concentration and amounted to .apprx. 40% of aterial blood value for xylene. The coefficient between the concentration of unmetabolized xylene in s.c. fat and inspiratory air was 525 after 8 h exposure.

This publication has 3 references indexed in Scilit: