An extension of secondary structure prediction towards the production of tertiary structure
- 11 March 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 280 (1) , 141-146
- https://doi.org/10.1016/0014-5793(91)80223-p
Abstract
Secondary structure prediction parameters and optimised decision constants for use with the method of Garnier et al. [(1978) J. Mol. Biol. 120, 97–120] have been derived for two new and distinct substates of β‐structure. These we term internal and external on the basis of their hydrogen bonding patterns. The profiles of the amino acids for several of the parameters are considerably different in the two substates. Predictions using the new parameters attempt to distinguish the strands at the core of the β‐sheet from those at its edges an so restrict the possible topologies in tertiary structure prediction. The potential application of this parameters is illustrated for the class of β/α proteins.Keywords
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