Synthesis of benzhydryl 2.alpha.-(chloromethyl)-2.beta.-methyl-6,6-dihydropenam-3.alpha.-carboxylate 1,1-dioxide: the 2.alpha.-isomer of the potent .beta.-lactamase inhibitor, BL-P2013

This publication has 7 references indexed in Scilit:

• Inhibition of β-lactamase-I by 6-β-sulfonamidopenicillanic acid sulfones: Evidence for conformational change accompanying the inhibition process
  Bioorganic Chemistry, 1985
• 6-(Methoxymethylene)penicillanic acid: a new .beta.-lactamase inactivator
  The Journal of Organic Chemistry, 1985
• Synthesis and .beta.-lactamase inhibitory properties of 2.beta.-(chloromethyl)-2.alpha.-methylpenam-3.alpha.-carboxylic acid 1,1-dioxide
  Journal of Medicinal Chemistry, 1981
• Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6.alpha.- and 6.beta.-monodeuterio and of 6,6-dideuterio derivatives with RTEM .beta.-lactamase from Escherichia coli. Crystal structure of penicillanic acid sulfone
  Biochemistry, 1981
• CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization
  Antimicrobial Agents and Chemotherapy, 1978
• A sulfone .BETA.-lactam compound which acts as a .BETA.-lactamase inhibitor.
  The Journal of Antibiotics, 1978
• Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus
  Antimicrobial Agents and Chemotherapy, 1977