REASSORTMENT OF LYMPHOCYTES IN LYMPH FROM NORMAL AND ALLOGRAFTED SHEEP

  • 1 January 1977
    • journal article
    • research article
    • Vol. 87  (1) , 59-80
Abstract
The distribution and nature of surface immunoglobulin-bearing (SIg) cells were studied in various sources of lymph from normal sheep and from sheep bearing renal autografts and renal allografts. In normal sheep, 12.2% .+-. 1.5 of all mononuclear cells in peripheral lymph had SIg and, of these, more than 50% were monocytes and macrophages. Less than 6% of the lymphocytes in peripheral lymph carried SIg. In contrast, 24.7% .+-. 1.3 of the mononuclear cells in central lymph had SIg, and all of the labeled cells were lymphocytes. The frequencies of SI g cells in peripheral lymph issuing from renal autografts and from renal allografts were 6.7% .+-. 1.3 and 6.9% .+-. 0.8, respectively; the labeled cells were predominantly lymphocytes. The proportion of SIg cells in central lymph from graft-bearing sheep was similar to that from normal sheep. The differences between central lymph and peripheral lymph from normal and graft-bearing sheep probably reflect a restriction on the passage of SIg cells through capillary endothelium in nonlymphoid tissues.