Drucksenkender Effekt und Nebenwirkungen von Levobunolol-Augentropfen 0,5% und 1,0%, verglichen mit Timolol-Augentropfen 0,5% bei Patienten mit Weitwinkelglaukomen

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Abstract
Fifty patients with open-angle glaucoma were treated twice daily for one year with topical 0.5% levobunolol, 1% levobunolol, or 0.5% timolol. Both concentrations of levobunolol were as effective as timolol in reducing intraocular pressure over the one-year period. At the concentrations tested, levobunolol and timolol decreased heart rate to a similar extent, suggesting that systemic absorption occurred after topical instillation. In all three treatment groups, clinically insignificant changes in blood pressure were observed sporadically throughout the one-year period. Very few clinically significant toxic ocular reactions were observed.