Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"
- 12 January 2007
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5809) , 187
- https://doi.org/10.1126/science.1129402
Abstract
Herbert et al . (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.Keywords
This publication has 8 references indexed in Scilit:
- A Common Genetic Variant Is Associated with Adult and Childhood ObesityScience, 2006
- ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult ObesityDiabetes, 2006
- Association of genetic lociNeurology, 2004
- Genome-wide Linkage Analysis for Severe Obesity in French Caucasians Finds Significant Susceptibility Locus on Chromosome 19qDiabetes, 2004
- VNTR Polymorphism of the Insulin Gene and Childhood Overweight in a General PopulationObesity Research, 2004
- Family-Based Tests of Association in the Presence of LinkageAmerican Journal of Human Genetics, 2000
- A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10Nature Genetics, 1998
- Testing Association between Candidate-Gene Markers and Phenotype in Related Individuals, by Use of Estimating EquationsAmerican Journal of Human Genetics, 1997