STATs Find That Hanging Together Can Be Stimulating
- 9 August 1996
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5276) , 750-751
- https://doi.org/10.1126/science.273.5276.750
Abstract
A report in this week's issue of Science by Xu et al . ( p. 794 ) shows that homodimers of various kinds of STATs (signal transducers and activators of transcription) bind to regulatory regions of the gene for the interferon-γ gene, each with a slightly different binding site. In their Perspective, Leung, Li, and Stark explain how these cooperating STAT dimers, which interact via their NH 2 terminals, can determine the specificity of the cytokine response.This publication has 14 references indexed in Scilit:
- Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal DomainScience, 1996
- Intracellular signalling: Putting JAKs on the kinase MAPCurrent Biology, 1996
- Identification of a Stat Gene That Functions in Drosophila DevelopmentCell, 1996
- Function of Stat2 Protein in Transcriptional Activation by Alpha InterferonMolecular and Cellular Biology, 1996
- Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.Proceedings of the National Academy of Sciences, 1995
- TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT PathwayAnnual Review of Biochemistry, 1995
- A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.Genes & Development, 1995
- Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine ReceptorsScience, 1995
- Role of STAT2 in the Alpha Interferon Signaling PathwayMolecular and Cellular Biology, 1995
- Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactionsPublished by Elsevier ,1994