Enhancement of the delayed-type hypersensitivity reaction by oxazaphosphorines.

  • 1 September 1987
    • journal article
    • review article
    • Vol. 9  (9) , 605-10
Abstract
Delayed hypersensitivity reactions include tuberculin type, Jones Mote type reactions and contact sensitivity. These reactions are increased in guinea pigs and other species by pretreating the animals with a single dose of up to 300 mg/kg cyclophosphamide (CY). CY also reverses immunological tolerance and other forms of immunological unresponsiveness, including antigenic competition. Regulation of these hypersensitivity responses may be controlled by CY-sensitive B- or T-suppressor cells, depending on the species and the model. CY does not appear to act by increasing IL-2 production in the same way as other anti-cancer agents.

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