3α-Hydroxysteroid Dehydrogenase in Animal and Human Tissues
- 1 January 2001
- journal article
- review article
- Published by Springer Nature in Biochemistry (Moscow)
- Vol. 66 (3) , 256-266
- https://doi.org/10.1023/a:1010291527744
Abstract
This review analyzes data on the biological role of 3α-hydroxysteroid dehydrogenase (3α-HSD) in animal and human tissues and describes its main characteristics, mechanism of action, and regulation of activity. Based on published data, a scheme for the actions of androgen, progestin, and glucocorticoids involving the participation of 3α-HSD is proposed. According to this scheme, in the mechanism of steroid action 3α-HSD not only regulates the concentration of the main effector androgen, 5α-dihydrotestosterone, in target cells, but also switches androgen, progestin, and glucocorticosteroid genomic activity to non-genomic activity.Keywords
This publication has 0 references indexed in Scilit: