An H‐Deficient Blood with Normal H Transferase Levels

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Abstract
An H-deficient blood is described which, unlike other H-deficient, Bombay and para-Bombay bloods, has normal H transferase levels. In previous examples of Bombay and para-Bombay phenotypes the absence of H transferase has explained the lack of H substrate and, therefore, the weak A and B antigens which are characteristic of these phenotypes. This explanation does not hold here. Apparently the biochemical block must be further back, either in the enzymes synthesizing the oligosaccharide chains, or in those making the GDP-fucose substrate for the H and the Le gene-specified fucosyltransferases. Inhibition of the synthesis of Leb substance and H substance.sbd.although patient saliva contains the Le gene-specified transferase.sbd.supports this proposition.

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