Cardiovascular Responses to Epinephrine Before and After Denervation of the Pressoreceptors

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Abstract
Dogs were anesthetized by intraven. barbital 0.001, 0.01, 0.05, 0.1, 0.5, 1, 5, and 10 ug. of l-epinephrine per kg. Pressoreceptors were denervated in stages: (1) right carotid sinus; (2) left sinus; (3) right vagus to deafferent aortic arch; (4) left vagus nerve. Pressure responses showed no significant effect from denervation (P> 0.1) at any dose level. Duration of the pressor responses either showed no material effect from denervation or was longer with the pressoreceptors intact: at 5 [mu]g., 0.005 < PP < 0.01. After denervations, epinephrine did not produce arrhythmia. In the presence of circulating epinephrine, the pressoreceptor reflexes are incapable of moderating blood pressure responses; they slow the heart. This effect in conjunction with the myocardial action of epinephrine leads to arrhythmias after the larger doses.

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