Expression of Lacto Series Type 2 Antigens in Human Renal Cell Carcinoma and Its Clinical Significance
- 1 March 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 81 (5) , 352-358
- https://doi.org/10.1093/jnci/81.5.352
Abstract
We performed immunohistochemical examination of serial sections of human fetal and adult renal tissue as well as human renal carcinoma tissue, using monoclonal antibodies T5A7, 1B2, FH2, FH4, and FH6. These monoclonal antibodies were directed to lacto series type 2 antigens with sugar-chain structures: lactosylceramide, lactoneotetraosylceramide (paragloboside), Lex (a chemically well-defined fucosyl carbohydrate antigen), difucosyl Lex, and sialosyl-difucosyl Lex, respectively. The staining pattern in fetal renal tissue changed significantly according to the stage of organogenesis. In addition, expression of the antigens, especially paragloboside and sialosyl-difucosyl Lex was closely related to the prognosis of the patient. These results suggest that the expression of a series of oncofetal antigens in development or differentiation of organs is reflected in the reversion to an immature pattern of antigenic expression in tumor tissue. The pattern of antigen expression in renal tumors offers a good criterion for ascertaining the degree of tumor differentiation and malignancy and is valuable for determining prognosis. [J Natl Cancer Inst 81:352–358, 1989]Keywords
This publication has 14 references indexed in Scilit:
- LOCATION AND DISTRIBUTION OF DIFUCOGANGLIOSIDE (VI3NEUACV3III3FUC2NLC6) IN NORMAL AND TUMOR-TISSUES DEFINED BY ITS MONOCLONAL-ANTIBODY FH61985
- Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6).Journal of Biological Chemistry, 1984
- Localization and alteration of mono-, di-, and trifucosyl alpha 1----3 type 2 chain structures during human embryogenesis and in human cancer.The Journal of Experimental Medicine, 1984
- Monoclonal antibody specific for lactosylceramide.Journal of Biological Chemistry, 1984
- Novel fucolipids accumulating in human adenocarcinoma. II. Selective isolation of hybridoma antibodies that differentially recognize mono-, di-, and trifucosylated type 2 chain.Journal of Biological Chemistry, 1984
- Novel fucolipids accumulating in human adenocarcinoma. I. Glycolipids with di- or trifucosylated type 2 chain.Journal of Biological Chemistry, 1984
- Human cancer-associated gangliosides defined by a monoclonal antibody (IB9) directed to sialosylα2→6galactosyl residue: A preliminary noteBiochemical and Biophysical Research Communications, 1983
- Two monoclonal anticarbohydrate antibodies directed to glycosphingolipids with a lacto-N-glycosyl type II chain.Journal of Biological Chemistry, 1981
- The hapten structure of a developmentally regulated glycolipid antigen (SSEA-1) isolated from human erythrocytes and adenocarcinoma: A preliminary noteBiochemical and Biophysical Research Communications, 1981
- ELECTRON MICROSCOPIC OBSERVATIONS ON SPECIALIZATIONS OF CELL SURFACE IN RENAL CLEAR CELL CARCINOMA1965