Optical particle detection integrated in a dielectrophoretic lab-on-a-chip
- 19 December 2001
- journal article
- Published by IOP Publishing in Journal of Micromechanics and Microengineering
- Vol. 12 (1) , 7-12
- https://doi.org/10.1088/0960-1317/12/1/302
Abstract
The design and fabrication of a dielectrophoretic 'lab-on-a-chip' device for bioparticle processing and counting is presented. The device consists of a multi-layer travelling wave dielectrophoretic electrode array for manipulating particles and/or fluids, microchannels for delivering samples and optical fibres for counting particles and/or measuring their velocities. Single particles were detected optically using either light scattering or fluorescence emission. The technology described in this study is potentially applicable to a range of particulate diagnostic systems.Keywords
This publication has 16 references indexed in Scilit:
- The dielectrophoretic levitation and separation of latex beads in microchipsElectrophoresis, 2001
- Nanoscale chemical analysisTrAC Trends in Analytical Chemistry, 2000
- Design and fabrication of travelling wave dielectrophoresis structuresJournal of Micromechanics and Microengineering, 2000
- Advances in polymer integrated opticsIEEE Journal of Selected Topics in Quantum Electronics, 2000
- An Integrated Nanoliter DNA Analysis DeviceScience, 1998
- Integrated bio/chemical microsystems employing optical detection: the clip-onJournal of Micromechanics and Microengineering, 1998
- Large-area travelling-wave dielectrophoresis particle separatorJournal of Micromechanics and Microengineering, 1997
- Design and fabrication of low-loss polymer waveguide components for on-chip optical interconnectionIEEE Photonics Technology Letters, 1996
- Electromanipulation and separation of cells using travelling electric fieldsJournal of Physics D: Applied Physics, 1996
- Dielectrophoresis: Using Inhomogeneous AC Electrical Fields to Separate and Manipulate CellsCritical Reviews in Biotechnology, 1996