Placebo-Controlled Double-Blind Study Examining the Effectiveness of an Hypericum Preparation in 105 Mildly Depressed Patients
- 1 January 1994
- journal article
- research article
- Published by SAGE Publications in Journal of Geriatric Psychiatry and Neurology
- Vol. 7 (1_suppl) , 9-11
- https://doi.org/10.1177/089198879400701s04
Abstract
One hundred and five outpatients with mild depressions of short duration were treated in a double-blind study with either 3 x 300 mg hypericum extract or placebo. The therapy phase was 4 weeks. The effectiveness was judged according to the Hamilton Depression Scale after 2 and 4 weeks. The values of the mean basic score in these periods fell from 15.8 to 9.6 or 7.2 in the active group, and in the placebo group, from 15.8 to 12.3 and 11.3. The difference between active and placebo groups were statistically significant with P < .05 and P < .01 achieved after 2 and 4 weeks, respectively. In the active group, 28 of 42 patients (67%) and, in the placebo group, 13 of 47 Patients (28%) responded to treatment. Notable side effects were not found.Keywords
This publication has 1 reference indexed in Scilit:
- Diagnosenschlüssel und Glossar psychiatrischer KrankheitenPublished by Springer Nature ,1980