Endothelial β 3 -Adrenoceptors Mediate Vasorelaxation of Human Coronary Microarteries Through Nitric Oxide and Endothelium-Dependent Hyperpolarization
Open Access
- 24 August 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 110 (8) , 948-954
- https://doi.org/10.1161/01.cir.0000139331.85766.af
Abstract
Background— Coronary vessel tone is modulated in part by β-adrenergic relaxation. However, the implication of specific β-adrenoceptor subtypes and their downstream vasorelaxing mechanism(s) in human coronary resistance arteries is poorly defined. β3-Adrenoceptors were recently shown to vasodilate animal vessels and are expressed in human hearts.Keywords
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