GENDER DIFFERENCES IN PROSTAGLANDIN RECEPTORS OF RAT AORTA
Open Access
- 1 January 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 72 (1) , 10-12
- https://doi.org/10.1111/j.1476-5381.1981.tb09097.x
Abstract
The maximal contractile response to the prostaglandin endoperoxide H2 analogue U46619, prostaglandins E2, D2 and F2α and the sensitivity of the superfused aorta preparation to these drugs (except PGF2α) is greater in the male than the female rat. In contrast, gender differences were not observed in the response to noradrenaline or 5-hydroxytryptamine. In previous studies, testosterone unlike oestrogen or progesterone, increased the response of both rabbit and rat aorta to U46619. We conclude that prostaglandin receptors in rat thoracic aorta may be hormonally regulated.Keywords
This publication has 9 references indexed in Scilit:
- Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitroProstaglandins and Medicine, 1978
- Comparison of calcium association constants and ionophoretic properties of some prostaglandins and ionophoresArchives of Biochemistry and Biophysics, 1978
- Effects of prostaglandins and oxytocin on calcium release from a uterine microsomal fraction.Journal of Biological Chemistry, 1977
- Vascular smooth muscle and prostaglandins.1976
- Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.Proceedings of the National Academy of Sciences, 1975
- Comparison of aortic calcium and contractility in male, female and lactating female rats.1975
- Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory DrugsNature, 1969
- ON THE CONTRACTILE RESPONSE OF THE ISOLATED RAT UTERUS TO PROSTAGLANDIN E1Canadian Journal of Physiology and Pharmacology, 1967