Variety in the level of gene control in eukaryotic cells
- 1 June 1982
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 297 (5865) , 365-371
- https://doi.org/10.1038/297365a0
Abstract
In light of present progress in the understanding of how messenger RNA is constructed in eukaryotic cells, the levels of gene control are discussed. Transcriptional control, assessed by the rate of synthesis of specific nuclear RNA, is strongly indicated to be the most frequent level of control. Definition of eukaryotic transcription units as simple (encoding one protein) and complex (encoding two or more proteins) affords a framework in which to discuss control at the level of RNA processing for which several examples also are known. Finally, differential stability of cytoplasmic mRNAs and differential translation, both well established, are briefly described.Keywords
This publication has 138 references indexed in Scilit:
- Genetic regulatory mechanisms in the synthesis of proteinsPublished by Elsevier ,2010
- Regulation of translation in L-cells infected with reovirusJournal of Molecular Biology, 1981
- Controls of RNA splicing and termination in the major late adenovirus transcription unitNature, 1981
- Control of messenger RNA concentration by differential cytoplasmic half-lifeJournal of Molecular Biology, 1981
- The reactivation of developmentally inert 5S genes in somatic nuclei injected into Xenopus oocytesNature, 1981
- Transcription units of adenovirus type 2Journal of Molecular Biology, 1980
- Galactose regulation in Saccharomyces cerevisiaeJournal of Molecular Biology, 1979
- Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genomeJournal of Molecular Biology, 1978
- 3′ Non-coding region sequences in eukaryotic messenger RNANature, 1976
- Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNAJournal of Molecular Biology, 1973