Serum and Cerebrospinal-Fluid Transaminase Concentrations in Various Neurologic Disorders

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Abstract
THE enzyme glutamic oxalacetic transaminase (GOT) is widely distributed in animal tissues but appears to be most concentrated in the myocardium, liver, skeletal muscle, brain and kidney.1 2 3 It has been repeatedly demonstrated that a rise in the serum level of GOT follows acute damage to the myocardium, liver and skeletal muscle. Relatively little work has been done on the effect of neurologic disorders on GOT levels. Wakim and Fleisher4 have demonstrated that experimental cerebral infarction in dogs leads to a marked increase in the activity of GOT in cerebrospinal fluid roughly proportional to the extent and severity of the infarct. . . .

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