In-vitro activities of trospectomycin, cefpodoxime, and second-generation cephalosporins against Haemophilus influenzae type b
- 31 December 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 25 (4) , 535-539
- https://doi.org/10.1093/jac/25.4.535
Abstract
The in vitro activities of trospectomycin, cefpodoxime, cefamandole, cefonicid, and cefuroxime against .beta.-lactamase-negative and -positive invasive clinical isoaltes of Haemophilus influenzae type b were determined by the agar dilution method. Trospectomycin and cefpodoxime inhibited 90% of the strains at concentrations of 5 and 0.06 mg/l, respectively, and no differences between the susceptibilities of the .beta.-lactamase-negative and -positive strains were noted. The activity of cefpodoxime was minimally affected by increased inoculum size, but significant inoculum effects were noted with cefamandole, cefonicid, and cefuroxime with .beta.-lactamase positive strains.This publication has 1 reference indexed in Scilit:
- In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analogAntimicrobial Agents and Chemotherapy, 1988