IDENTIFICATION OF INVITRO METABOLITES OF DELTA-1-TETRAHYDROCANNABINOL FORMED BY HUMAN LIVERS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (4) , 297-301
Abstract
Metabolism of .DELTA.1-tetrahydrocannabinol (.DELTA.1-THC) in humans, was studied in vitro with the 10,000 g supernatant fraction of 3 human livers. One of the livers (H-13) showed very high enzyme activity compared to the other 2. The metabolites were characterized by their mass spectra and in most cases by comparison of their mass spectra and chromatographic properties with those of available synthetic references. The metabolic pattern was similar in all 3 livers, with 7-hydroxy-.DELTA.1-THC as the most abundant metabolite. They all formed compounds oxygenated in the 6-position. Sidechain oxygenation was most pronounced with H-13; trace mounts of 7-hydroxy-epoxide were formed by livers H-13 and H-15.

This publication has 0 references indexed in Scilit: