Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam.
- 1 June 1986
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 21 (6) , 647-653
- https://doi.org/10.1111/j.1365-2125.1986.tb05229.x
Abstract
The cognitive function and psychomotor performance of 10 healthy male volunteers were measured following single oral doses of: zopiclone (7.5 mg), flurazepam (15 mg), lormetazepam (1 mg), triazolam (0.25 mg) and placebo. The performance tests selected (stroop task, five choice serial reaction time, memory span, logical reasoning, mood and saccadic eye movement analysis) were thought to reflect aspects of normal daily activity. The tests demonstrated a clear reduction of performance for all active treatments. No drug emerged as the most potent sedative overall, as each of the tests was affected to a different degree by each drug. Drug effects were not qualitatively different between active treatments so that zopiclone was indistinguishable from the three benzodiazepines with which it was compared.This publication has 16 references indexed in Scilit:
- Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance.British Journal of Clinical Pharmacology, 1984
- Rate of entrance of benzodiazepines into the brain determined by eye movement recording.British Journal of Clinical Pharmacology, 1983
- Sedative-hypnotics and human performancePsychopharmacology, 1982
- The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.British Journal of Clinical Pharmacology, 1981
- Comparative study of zopiclone, a novel hypnotic, and three benzodiazepinesEuropean Journal of Clinical Pharmacology, 1980
- Factor Analytic and Reliability Studies on the Activation-Deactivation Adjective Check ListPsychological Reports, 1978
- A 3 min reasoning test based on grammatical transformationPsychonomic Science, 1968
- The stroop color-word test: A reviewActa Psychologica, 1966