Possible role of a retrovirus in the expression of tumor-specific antigens of the meth a sarcoma.

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Abstract
The serologically defined tumor‐specific surface antigen (TSSA) of the chemically‐induced BALB/c Meth A sarcoma, highly restricted to one of 20 sarcomas of BALB/c origin, has been detected on a Moloney murine sarcoma virus (Mo‐MuSV)‐transformed BALB/c 3T3 cell line, designated IIA(v). The immunogenicity of the IIA(v) cell in tumor‐rejection assays was specific for the Meth A sarcoma, supporting the evidence for a close relationship between the TSSA and the tumor‐associated transplantation antigen (TATA) of this tumor. Infection of SC‐I cells with retroviruses present in cultured filtrates of IIA(v) cells resulted in Meth A antigen expression. The retroviruses associated with Meth A antigen expression have been tentatively identified as replication and/or transformation‐defective XC‐ MuLV. The possible roles of Mo‐MuSV and cellular genes of the BALB/c strain of mice in the expression of the Meth A antigen are discussed.