2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia
- 2 February 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 247 (4942) , 571-574
- https://doi.org/10.1126/science.2154034
Abstract
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.This publication has 13 references indexed in Scilit:
- Quisqualate neurotoxicity: A delayed, CNQX-sensitive process triggered by a CNQX-insensitive mechanism in young rat hippocampal slicesNeuroscience Letters, 1989
- Quisqualate Activates a Rapidly Inactivating High Conductance Ionic Channel in Hippocampal NeuronsScience, 1989
- Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor AntagonistsScience, 1988
- A new and specific non-NMDA receptor antagonist, FG 9065, blocks L-AP4-evoked depolarization in rat cerebral cortexEuropean Journal of Pharmacology, 1988
- Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal InjuryJournal of Cerebral Blood Flow & Metabolism, 1987
- Molecular target size of NMDA antagonist binding sitesEuropean Journal of Pharmacology, 1987
- A new type of glutamate receptor linked to inositol phospholipid metabolismNature, 1987
- Calcium discriminates two [3H]kainate binding sites with different molecular target sizes in rat cortexNeuroscience Letters, 1986
- Shared motor innervation between dynamic and static intrafusal muscle fibers in the monkeyNeuroscience Letters, 1985
- Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 1984