Pharmacokinetics and Antiepileptic Activity of Valproyl Hydroxamic Acid Derivatives
- 1 January 1997
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (2) , 213-217
- https://doi.org/10.1023/a:1012009012850
Abstract
Purpose. To explore the utilization of seven novel hydroxamic acid derivatives of valproic acid (VPA) as new antiepileptics. Methods. The study was carried out by investigating the pharmacokinetics...Keywords
This publication has 12 references indexed in Scilit:
- Pharmacokinetic Analysis and Antiepileptic Activity of Tetra-Methylcyclopropane Analogues of ValpromidePharmaceutical Research, 1996
- Can we develop improved derivatives of valproic acid?Pharmacy World & Science, 1994
- Pharmacokinetic Analysis of the Structural Requirements for Forming “Stable” Analogues of ValpromidePharmaceutical Research, 1992
- In vitro screening for anticonvulsant-induced teratogenesis: Structure-activity relationships in the barbiturate and branched chain carboxylic acid classesToxicology in Vitro, 1991
- Clinical Pharmacology of ValpromideClinical Pharmacokinetics, 1991
- Pharmacokinetics and Anticonvulsant Activity of Three Monoesteric Prodrugs of Valproic AcidPharmaceutical Research, 1991
- IDENTIFICATION AND EVALUATION OF O-ALKYL SUBSTITUTED HYDROXAMIC ACIDS AS POTENT INVITRO INHIBITORS OF THE HEPATIC GLYCINE CLEAVAGE SYSTEM AND INVESTIGATION OF THEIR ACTION ON INVIVO CENTRAL NERVOUS-SYSTEM GLYCINE CONCENTRATION1989
- Rapid Gas Chromatographic Assay for Monitoring Valproic Acid and Valpromide in PlasmaJournal of Pharmaceutical Sciences, 1984
- Antiepileptic Drug Development ProgramCleveland Clinic Journal of Medicine, 1984
- A comparative study on the pharmacokinetics of valpramide after intravenous administration in dogsJournal of Pharmacy and Pharmacology, 1983