RADIORESISTANT INHIBITION OF LYMPHOMA GROWTH IN CONGENITALLY ATHYMIC (NUDE) MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (2) , 394-398
Abstract
Several murine tumors were used to determine whether the phenomenon of tumor inhibition in athymic nude mice reported previously could be extended to other tumor systems in nude and conventional mice. The results with the L5MF-22 tumor line were confirmed, and similar data were obtained with the K36 leukemia of AKR mice and the LAF-17 leukemia of B10.A origin. This phenomenon of tumor inhibition is called, tentatively, radioresistant inhibition of tumor and may be explained by 1 of several possibilities. The immunological origin of such tumor inhibition is supported by various observations. The data on tumor cell proliferation in spleens and liver of lethally irradiated mice were similar to previous findings on hemopoietic histocompatibility-incompatible lymphomas. Additionally the nude mice were stronger responders against lymphoma cells than were conventional hosts. Another explantation is that the tumor inhibition is due to natural cytotoxicity.