Inhibitor of Factor VIII in Mild Haemophilia
- 1 September 1969
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 17 (3) , 283-288
- https://doi.org/10.1111/j.1365-2141.1969.tb01374.x
Abstract
Summary. Two patients with mild haemophilia developed inhibitors of Factor VIII during replacement therapy to cover major surgery. The inhibitors inactivated not only transfused antihaemophilic factor but also the patient's own Factor VIII and temporarily converted them to severe haemophiliacs. The activity of the inhibitors rapidly declined, possibly as a result of steroid therapy, and both patients eventually regained their previously mild haemophilic state.Keywords
This publication has 11 references indexed in Scilit:
- TWO FORMS OF HÆMOPHILIA?The Lancet, 1968
- Antibody nature of an AHG (Factor VIII)inhibitorThe Journal of Pediatrics, 1968
- Major surgery in haemophilia. Prolonged substitution therapy for surgical treatment of haemophilic cyst and pathological fracture of the femurBritish Journal of Surgery, 1968
- Characterization and Properties of an Inhibitor of Factor VIII in the Plasma of Patients with Hemophilia A Following Repeated TransfusionsBlood, 1967
- The Immunologic Character of Acquired Inhibitors of Antihemophilic Globulin (Factor VIII) and the Kinetics of Their Interaction with Factor VIII*Journal of Clinical Investigation, 1967
- CIRCULATING ANTICOAGULANTSMedicine, 1961
- A Method for the Study of Antihaemophilic Globulin Inhibitors with Reference to Six CasesBritish Journal of Haematology, 1959
- Assay of Plasma Antihaemophilic Globulin (AHG)*British Journal of Haematology, 1959
- CIRCULATING ANTICOAGULANTSBritish Medical Bulletin, 1955