Renal vasculitis--an update in 2004

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Abstract
The primary systemic vasculitides are a group of inflammatory diseases of unknown cause, which are usually fatal if untreated. Their classification has been harmonized over the last decade and an evidence base for treatment decisions is emerging. Current therapy saves lives, salvages organ function and reduces morbidity. However, mortality and end-stage renal failure (ESRF) rates remain high, up to 50% relapse and the consequences of treatment-related toxicity rival those of the underlying diseases. There is a need for safer, more effective therapy.