Impaired Cellular Resistance to Herpes-Simplex Virus in Wiskott-Aldrich Syndrome

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Abstract
THIS familial syndrome of eczema, thrombocytopenia and recurrent infection was described by Wiskott1 in 1937, but it was not until 1954 that Aldrich, Steinberg and Campbell2 defined it as a sex-linked recessive disease. The majority of children afflicted with this baffling disorder have died as a result of overwhelming bacterial infection. Recently, however, visceral invasion by measles virus and cytomegalovirus has been described as an additional microbial complication.3 In our own hospital, within a period of two and a half years, we observed an alarming progression of primary herpetic gingivostomatitis in 3 boys with this syndrome. Two of these patients . . .